Structural characterization of a variety of DNA polymerases has likened the polymerase domain to a hand that grasps DNA with functional subdomains referred to as fingers, palm and thumb. The solution structure of the African swine fever virus DNA polymerase X indicates that it does not have a hand-like architecture and suggests a mechanism by which the polymerase may compensate for the lack of a dedicated DNA binding subdomain.
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Acknowledgements
We thank G. Mullen, I.-J. Byeon, and M.-D. Tsai for generously providing the coordinates prior to publication and K. Bebenek and J. Horton for critical reading of the manuscript.
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Beard, W., Wilson, S. DNA polymerases lose their grip. Nat Struct Mol Biol 8, 915–917 (2001). https://doi.org/10.1038/nsb1101-915
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DOI: https://doi.org/10.1038/nsb1101-915
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