The structure of an lnterleukin-4 mutant shows that an uncompensated charge disables the interaction between cytokine and low-affinity receptor.
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Müller, T., Sebald, W. & Oschkinat, H. Antagonist design through forced electrostatic mismatch. Nat Struct Mol Biol 1, 674–676 (1994). https://doi.org/10.1038/nsb1094-674
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DOI: https://doi.org/10.1038/nsb1094-674
