Crystal structures of the Escherichia coli DNA replication γ clamp loading complex and of a subunit of the clamp loader bound to a β clamp monomer provide a physical framework in which to view ATP-dependent modulation of γ complex–β interactions. The structural data suggest how the β ring is opened and loaded onto DNA in the absence of a direct interaction between the γ complex and the β dimer interface.
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Bloom, L., Goodman, M. A sliding clamp monkey wrench. Nat Struct Mol Biol 8, 829–831 (2001). https://doi.org/10.1038/nsb1001-829
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DOI: https://doi.org/10.1038/nsb1001-829