The structure and dynamics of the first KH domain of FMR1 — the protein responsible for fragile X syndrome — reveal that an exposed loop is highly flexible despite containing a GxxG motif that is well conserved throughout the KH family. We suggest that this region provides a putative binding surface for RNA recognition.
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Musco, G., Kharrat, A., Stier, G. et al. The solution structure of the first KH domain of FMR1, the protein responsible for the fragile X syndrome. Nat Struct Mol Biol 4, 712–716 (1997). https://doi.org/10.1038/nsb0997-712
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DOI: https://doi.org/10.1038/nsb0997-712
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