NMR analyses of variants of the p53 tumor suppressor protein that either contain or lack the C-terminus reveal that the C-terminus neither interacts with other regions of p53 nor has an impact on the conformation of the rest of the molecule. Nevertheless, the C-terminus is likely to be critical for regulation of p53 function.
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Ahn, J., Prives, C. The C-terminus of p53: the more you learn the less you know. Nat Struct Mol Biol 8, 730–732 (2001). https://doi.org/10.1038/nsb0901-730
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DOI: https://doi.org/10.1038/nsb0901-730
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