IgA triggers immune responses by binding to Fc receptors on cells of the immune system. The structure of IgA1-Fc in a complex with two molecules of FcαRI provides clues that may explain the selectivity of IgA-mediated immune events.
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References
Monteiro, R.C. & Van De Winkel, J.G. Annu. Rev. Immunol. 21, 177–204 (2003).
Radaev, S. & Sun, P. Mol. Immunol. 38, 1073–1083 (2002).
Wurzburg, B.A. & Jardetzky, T.S. Mol. Immunol. 38, 1063–1072 (2002).
Raghavan, M. & Bjorkman, P.J. Annu. Rev. Cell Dev. Biol. 12, 181–220 (1996).
Kijimoto-Ochiai, S. Cell. Mol. Life. Sci. 59, 648–664 (2002).
Herr, A.B., Ballister, E.R. & Bjorkman, P.J. Nature 423, 614–620 (2003).
Ding, Y. et al. J. Biol. Chem. Epub ahead of print, 3 June 2003 (doi:10.1074/jbc.C300223200).
Huber, R., Deisenhofer, J., Colman, P.M., Matsushima, M. & Palm, W. Nature 264, 415–420 (1976).
Wan, T. et al. Nat. Immunol. 3, 681–686 (2002).
Maxwell, K.F. et al. Nat. Struct. Biol. 6, 437–442 (1999).
Sondermann, P. & Jacob, U. Biol. Chem. 380, 717–721 (1999).
Sondermann, P., Huber, R., Oosthuizen, V. & Jacob, U. Nature 406, 267–273 (2000).
Radaev, S., Motyka, S., Fridman, W.H., Sautes-Fridman, C. & Sun, P.D. J. Biol. Chem. 276, 16469–16477 (2001).
Garman, S.C., Kinet, J.P. & Jardetzky, T.S. Cell 95, 951–961 (1998).
Fan, Q.R. et al. Nature 389, 96–100 (1997).
Chapman, T.L., Heikema, A.P., West, A.P. & Bjorkman, P.J. Immunity 13, 727–736 (2000).
Herr, A.B., White, C.L., Milburn, C., Wu, C. & Bjorkman, P.J. J. Mol. Biol. 327, 645–657 (2003).
Garman, S.C., Wurzburg, B.A., Tarchevskaya, S.S., Kinet, J.P. & Jardetzky, T.S. Nature 406, 259–266 (2000).
Chapman, T.L., Heikeman, A.P. & Bjorkman, P.J. Immunity 11, 603–613 (1999).
Burmeister, W.P., Huber, A.H. & Bjorkman, P.J. Nature 372, 379–383 (1994).
Sauer-Eriksson, A.E., Kleywegt, G.J., Uhlen, M. & Jones, T.A. Structure 3, 265–278 (1995).
Deisenhofer, J. Biochemistry 20, 2361–2370 (1981).
Corper, A.L. et al. Nat. Struct. Biol. 4, 374–381 (1998).
Dykstra, M., Cherukuri, A., Sohn, H.W., Tzeng, S.J. & Pierce, S.K. Annu. Rev. Immunol. 21, 457–481 (2003).
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Wurzburg, B., Jardetzky, T. The IgA receptor complex: a two-for-one deal. Nat Struct Mol Biol 10, 585–587 (2003). https://doi.org/10.1038/nsb0803-585
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DOI: https://doi.org/10.1038/nsb0803-585
