The complex of Grb2-SH2 a BCR-Abl target peptide reveals that the peptide binds in a β-turn conformation; Trp 121 closes the binding site C-terminal to the phosphotyrosyl residue of the ligand and prevents it from assuming the expected extended conformation.
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Rahuel, J., Gay, B., Erdmann, D. et al. Structural basis for specificity of GRB2-SH2 revealed by a novel ligand binding mode. Nat Struct Mol Biol 3, 586–589 (1996). https://doi.org/10.1038/nsb0796-586
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DOI: https://doi.org/10.1038/nsb0796-586
