The structure determination of an anti-tumour antibody in complex with its Lewis Y carbohydrate antigen is a timely reminder of the historical and immunological importance of antibodies against polysaccharides, as well as their potential medical uses as diagnostics, therapeutics and vaccines.
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References
Livingston, P.O. Curr. Opin. Immunol. 4, 624–629 (1992).
Jeffrey, P.D. et al. Nature struct Biol. 2, 466–471 (1995).
Landsteiner, K. in The Specificity of Serological Reactions. pp. 107–110 (217 Dover Press, revised from the original 1945 edition, Harvard University Press; 1962).
Day, E.D. In Advanced Immunochemistry 234 (Wiley–Liss, 2nd Ed.; 1990).
Vyas, M.N. et al. J. molec. Biol. 231, 133–136 (1993).
Schneerson, R., Levi, L., Robbins, J.B., Bryla, D.M. Schiffman, G. & Lagergard, T. Infect. Immunity 60, 3528–3532 (1992).
Cisar, J., Kabat, E.A., Dorner, M.M. & Liao, J. J. exp. Med. 142, 435–459 (1975).
Padlan, E.A. & Kabat, E.A. Meth. Enzym. 203, 3–21 (1991).
Newman, B.A. & Kabat, E.A. J. Immun. 135, 1220–1231 (1985).
Fulton, R.J. & Davie, J.M. J. Immun. 133, 465–470 (1984).
Cygler, M., Rose, D.R. & Bundle, D.R. Science 253, 442–445 (1991).
Bundle, D.R. et al. Biochemistry 33, 5183–5192 (1994).
Zdanov, A. et al. Proc. natn. Acad. Sci. U.S.A 91, 6423–6427 (1994).
Evans, S.V., Rose, D.R., To, R., Young, N.M. & Bundle, D.R. J. molec. Biol. 241, 691–705 (1994).
Rose, D.R. et al. Prot. Sci. 2, 1106–1113 (1993).
Suh, S.W. et al. Proteins 1, 74–80 (1986).
Brady, R.L. et al. J. molec. Biol. 227, 253–264 (1992).
Essig, N.Z., Wood, J.F., Howard, A.J., Raag, R. & Whitlow, M. J. molec. Biol. 234, 897–901 (1993).
Quiocho, F.A. Biochem. Soc. Trans. 21, 442–448 (1993).
Vyas, N.K. Curr. Opin. struct. Biol. 1, 732–740 (1991).
Toone, E.J. Curr. Opin. struct. Biol. 4, 719–728 (1994).
Bundle, D.R. & Young, N.M. Curr. Opin. struct. Biol. 2, 666–673 (1992).
Wilson, I.A. & Stanfield, R.L. Curr. Opin. struct. Biol. 3, 113–118 (1993).
Siegall, C.B. et al. J. Immun. 152, 2377–2284 (1994).
Yokota, T., Milenic, D.E., Whitlow, M. & Schlom, J. Cancer Res. 52, 3402–3408 (1992).
Trail, P.A. et al. Science 261, 212–215 (1993).
Hakomori, S. Adv. Cancer Res. 52, 257–331 (1989).
Feizi, T. & Bundle, D. Curr. Opin. Struct. Biol. 4, 673–676 (1994).
Moffat, A. Science 268, 658–660 (1995).
Connolly, M.L. J. appl. Crystallogr. 16, 548–558 (1983).
Gelin, B.R. & Karplus, M. Biochemistry 18, 1256–1268 (1979).
Nicholls, A. GRASP: Graphical Representation & Analysis of Surface Properties. (Columbia University, New York; 1992).
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Wilson, I., Stanfield, R. A Trojan horse with a sweet tooth. Nat Struct Mol Biol 2, 433–436 (1995). https://doi.org/10.1038/nsb0695-433
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DOI: https://doi.org/10.1038/nsb0695-433
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