Expanding the genetic code by ribosome-mediated introduction of non-natural amino acids into proteins requires engineering of aminoacyl-tRNA synthetase–tRNA pairs. Structural information for pairs specific for tyrosine reveals how this goal may be achieved on a rational basis.
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Giegé, R. Genetic code expansion. Nat Struct Mol Biol 10, 414–416 (2003). https://doi.org/10.1038/nsb0603-414
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DOI: https://doi.org/10.1038/nsb0603-414
