Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Mini-proteins Trp the light fantastic

A new 20-residue peptide represents the smallest example to date of cooperatively folded tertiary structure. This achievement provides a new tool for elucidating protein conformational preferences. The mini-protein should serve as a fruitful platform for protein design.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Examples of mini-protein structures.

Accession codes

Accessions

Protein Data Bank

References

  1. Neidigh, J.W., Fesinmeyer, R.M. & Andersen, N.H. Nature Struct. Biol. 9, 425–430 (2002).

    Article  CAS  Google Scholar 

  2. Branden, C. & Tooze, J. Introduction to Protein Structure 2nd ed. (Garland, New York; 1999).

    Google Scholar 

  3. Luo, P. & Baldwin, R.L. Biochemistry 36, 8413–8421 (1997).

    Article  CAS  Google Scholar 

  4. Andersen, N.H. et al. J. Am. Chem. Soc. 119, 8547–8561 (1997).

    Article  CAS  Google Scholar 

  5. Dyson, H.J. & Wright, P.E. Methods Enzymol. 339, 258–270 (2001).

    Article  CAS  Google Scholar 

  6. Zarrinpar, A. & Lim, W.A. Nature Struct. Biol. 7, 611–613 (2000).

    Article  CAS  Google Scholar 

  7. McKnight, C.J., Matsudaira, P.T. & Kim, P.S. Nature Struct. Biol. 4, 180–184 (1997).

    Article  CAS  Google Scholar 

  8. Kannan N. & Vishveshwara S. Protein Eng. 13, 753–761 (2000).

    Article  CAS  Google Scholar 

  9. Cochran, A.G., Skelton, N.J. & Starovasnik, M.A. Proc. Natl. Acad. Sci. USA 98, 5578–5583 (2001).

    Article  CAS  Google Scholar 

  10. Blundell, T.L., Pitts, J.E., Tickle, I.J., Wood, S.P. & Wu, C.-W. Proc. Natl. Acad. Sci. USA 78, 4175–4179 (1981).

    Article  CAS  Google Scholar 

  11. Koh, J.T., Cornish, V.W. & Schultz, P.G. Biochemistry 36, 11314–11322 (1997).

    Article  CAS  Google Scholar 

  12. Chin, J.W. & Schepartz, A. J. Am. Chem. Soc. 123, 2929–2930 (2001).

    Article  CAS  Google Scholar 

  13. DeGrado, W.F., Summa, C.M., Pavone, V., Nastri, F. & Lombardi, A. Annu. Rev. Biochem. 68, 779–819 (1999).

    Article  CAS  Google Scholar 

  14. Imperiali, B. & Ottesen, J.J. J. Pept. Res. 54, 177–184 (1999).

    Article  CAS  Google Scholar 

  15. Kraulis, P.J. J. Appl. Crystallogr. 24, 946–950 (1991).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gellman, S., Woolfson, D. Mini-proteins Trp the light fantastic. Nat Struct Mol Biol 9, 408–410 (2002). https://doi.org/10.1038/nsb0602-408

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsb0602-408

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing