The scope of structural genomics has recently been estimated by simulation of several target selection strategies based on the currently known protein sequence families. Useful characterization of most protein sequences will be possible by protein structure modeling, if structures of ∼16,000 carefully selected protein domains are determined experimentally. In the absence of globally coordinated target selection, three times as many structures may be required.
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Acknowledgements
A.S. is grateful to S.K. Burley, J. Kuriyan, T. Gaasterland and other members of the New York Structural Genomics Research Consortium for many discussions about structural genomics, and to H.M. Moss and N. Eswar for comments on the manuscript. A.S. is an Irma T. Hirschl Trust Career Scientist. Support from The Merck Genome Research Institute, Mathers Foundation, and NIH is also acknowledged.
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Sali, A. Target practice. Nat Struct Mol Biol 8, 482–484 (2001). https://doi.org/10.1038/88529
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DOI: https://doi.org/10.1038/88529
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