Neuronal-Sec1 and syntaxin 1a, two proteins essential for membrane fusion, have now been crystallized in a complex with each other. The structure shows how the horseshoe-shaped nSec1 surrounds and holds syntaxin in a new conformation, and suggests that conformational changes in both nSec1 and syntaxin must take place for membrane fusion to proceed.
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Hanson, P. Sec1 gets a grip on syntaxin. Nat Struct Mol Biol 7, 347–349 (2000). https://doi.org/10.1038/75103
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DOI: https://doi.org/10.1038/75103
