Inhibitor binding to HIV protease affects and can be affected by protein motions. Knowledge of these motions will be of considerable importance for effective structure-based design of drugs.
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Wagner, G. The importance of being floppy. Nat Struct Mol Biol 2, 255–257 (1995). https://doi.org/10.1038/nsb0495-255
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DOI: https://doi.org/10.1038/nsb0495-255
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