The rate of refolding of cytochrome c is very rapid in the absence of non-native interactions , which raises questions about the general significance of both the rates and intermediates of protein folding that are normally observed.
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Creighton, T. The energetic ups and downs of protein folding. Nat Struct Mol Biol 1, 135–138 (1994). https://doi.org/10.1038/nsb0394-135
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DOI: https://doi.org/10.1038/nsb0394-135
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