The structure of one of the two catalytic domains of angiotensin converting enzyme in complex with an inhibitor provides molecular insights into the substrate- and inhibitor-binding profiles of this clinically important enzyme.
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References
Turner, A.J. & Hooper, N.M. Trends Pharmacol. Sci. 23, 177–183 (2002).
Natesh, R., Schwager, S.L.U., Sturrock, E.D. & Acharya, K.R. Nature 421, 551–554 (2003).
Hubert, C., Houot, A.-M., Corvol, P. & Soubrier, F. J. Biol. Chem. 266, 15377–15383 (1991).
Oppong, S.Y. & Hooper, N.M. Biochem. J. 292, 597–603 (1993).
Corvol, P. & Williams, T.A. in Handbook of Proteolytic Enzymes (eds. Barrett, A.J., Rawlings, N.D. & Woessner, J.F.) 1066–1076 (Academic Press, San Diego; 1998).
Rousseau, A., Michaud, A., Chauvet, M.-T., Lenfant, M. & Corvol, P. J. Biol. Chem. 270, 3656–3661 (1995).
Deddish, P.A. et al. Hypertension 31, 912–917 (1998).
Cushman, D.W. & Ondetti, M.A. Nat. Med. 5, 1110–1112 (1999).
Matthews, B.W. et al. Nat. New Biol. 238, 41–43 (1972).
Pantoliano, M.W., Holmquist, B. & Riordan, J.F. Biochemistry 23, 1037–1042 (1984).
Hooper, N.M. & Turner, A.J. Biochem. J. 241, 625–633 (1987).
Bernstein, K.E., Welsh, S.L. & Inman, J.K. Biochem. Biophys. Res. Commun. 167, 310–316 (1990).
Liu, X., Fernandez, M., Wouters, M.A., Heyberger, S. & Husain, A. J. Biol. Chem. 276, 33518–33525 (2001).
Brown, C.K. et al. Proc. Natl. Acad. Sci. USA 98, 3127–3132 (2001).
Vincent, B. et al. Br. J. Pharmacol. 121, 705–710 (1997).
Skidgel, R.A., Engelbrecht, S., Johnson, A.R. & Erdos, E.G. Peptides 5, 769–776 (1984).
Millican, P.E., Kenny, A.J. & Turner, A.J. Biochem. J. 276, 583–591 (1991).
Arndt, J.W. et al. Structure (Camb.) 10, 215–224 (2002).
Turner, A.J., Isaac, R.E. & Coates, D. Bioessays 23, 261–269 (2001).
Oefner, C., D'Arcy, A., Hennig, M., Winkler, F.K. & Dale, G.E. J. Mol. Biol. 296, 341–349 (2000).
Molinaro, G., Rouleau, J.L. & Adam, A. Curr. Opin. Pharmacol. 2, 131–141 (2002).
Tipnis, S.R. et al. J. Biol. Chem. 275, 33238–33243 (2000).
Donoghue, M. et al. Circ. Res. 87, E1–9 (2000).
Crackower, M.A. et al. Nature 417, 822–828 (2002).
Coates, D. et al. Biochemistry 39, 8963–8969 (2000).
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Hooper, N., Turner, A. An ACE structure. Nat Struct Mol Biol 10, 155–157 (2003). https://doi.org/10.1038/nsb0303-155
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DOI: https://doi.org/10.1038/nsb0303-155
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