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Structural lessons in DNA replication from the third domain of life

Nature Structural & Molecular Biology volume 10, pages 148–150 (2003)Cite this article

The high-resolution structure of the N-terminal half of an archaeal MCM protein domain sheds light on the enzyme's helicase activity and its role in DNA replication.

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Figure 1: Schematic comparison of the helicase activities of the three replicative helicases in the absence of a helicase loader.
Figure 2: Models of DNA replication initiation in eukarya and archaea.

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Acknowledgements

We would like to thank J. Aarons for the artwork of Figs. 1 and 2.

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Authors and Affiliations

  1. Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, 9600 Gudelsky Drive, Rockville, 20850, Maryland, USA

    Zvi Kelman

  2. Department of Molecular Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 97, New York, 10021, New York, USA

    Jerard Hurwitz

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Correspondence to Zvi Kelman.

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Kelman, Z., Hurwitz, J. Structural lessons in DNA replication from the third domain of life. Nat Struct Mol Biol 10, 148–150 (2003). https://doi.org/10.1038/nsb0303-148

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