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Neutron diffraction reveals the orientation of the headgroup of inositol lipids in model membranes

Nature Structural Biology volume 3, pages 125–127 (1996)Cite this article

Neutron diffraction studies show that the inositol ring in the headgroup of phosphatidylinositol extends perpendicular to the membrane surface but that phosphorylation of the 4-position causes the ring to tilt over.

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References

  1. Berridge, M.J. & Irvine, R.F. Nature 341, 197–205 (1989).

    Article  CAS  Google Scholar 

  2. Low, M.G. Biochim. Biophys. Acta 988, 427–454 (1989).

    Article  CAS  Google Scholar 

  3. Saltiel, A.R. Diabetes Care 13, 244–256 (1990).

    Article  CAS  Google Scholar 

  4. Divecha, N., Banfic, H & Irvine, R.F. Cell 74, 405–407 (1993).

    Article  CAS  Google Scholar 

  5. Young, R.C. et al. J. Med. Chem. 33, 641–646 (1990).

    Article  CAS  Google Scholar 

  6. Bruzik, K.S., Morocho, A.M., Jhon, D., Rhee, S.G. & Tsai, M. Biochemistry 31, 5183–5193 (1992).

    Article  CAS  Google Scholar 

  7. Giles, C.C.D. thesis, University of Leeds (1995).

    Google Scholar 

  8. Bushby, R.J., Byard, S.J., Hansbro, P.M. & Reid, D.G. Biochim. Biophys. Acta 1044, 231–236 (1990).

    Article  CAS  Google Scholar 

  9. Hansbro, P.M. et al. Biochim. Biophys. Acta 1112, 187–196 (1992).

    Article  CAS  Google Scholar 

  10. Büldt, G., Gally, H.U., Seelig, J. & Zaccai, G. J. Mol. Biol. 134, 673–691 (1979).

    Article  Google Scholar 

  11. Büldt, G., Gally, H.U., Seelig, A., Seelig, J. & Zaccai, G.J. Nature 271, 182–184 (1978).

    Article  Google Scholar 

  12. Bradshaw, J.P., Dempsey, C.E. & Watts, A. Molec. Membrane Biol. 11, 79–86 (1994)

    Article  CAS  Google Scholar 

  13. Weiner, M.C., King, G.I. & White, S.H. Biophys. J. 60, 568–576 (1991)

    Article  Google Scholar 

  14. Vinter, J.G., Davis, A. & Saunders, M.R. J. Comput. Aided Molecular Design. 1, 31–51 (1987).

    Article  CAS  Google Scholar 

  15. Skarjune, R. & Oldfield, E. Biochemistry 18, 5903–5909 (1979).

    Article  CAS  Google Scholar 

  16. Jarrell, H.C., Jovall, P.A., Giziewicz, J.B., Turner, L.A. & Smith, I.C.P. Biochemistry 26, 1805–1811 (1987).

    Article  CAS  Google Scholar 

  17. Jarell, H.C., Giziewicz, J.B. & Smith, I.C.P. Biochemistry 25, 3950–3957 (1986).

    Article  Google Scholar 

  18. Renou, J.-P., Giziewicz, J.B., Smith, I.C.P. & Jarell, H.C. Biochemistry 28, 1804–1814 (1989).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Preclinical Veterinary Sciences, Royal (Dick) School of Veterinary Science, University of Edinburgh, Summerhall, Edinburgh, EH9 1QH, UK

    Jeremy P. Bradshaw

  2. School of Chemistry, University of Leeds, Leeds, LS2 9JT, UK

    Richard J. Bushby & Colin C.D. Giles

  3. SmithKline Beecham Pharmaceuticals, The Frythe, Welwyn, Herts, AL6 9AR, UK

    Martin R. Saunders & David G. Reid

Authors
  1. Jeremy P. Bradshaw
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  2. Richard J. Bushby
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  3. Colin C.D. Giles
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  4. Martin R. Saunders
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  5. David G. Reid
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Bradshaw, J., Bushby, R., Giles, C. et al. Neutron diffraction reveals the orientation of the headgroup of inositol lipids in model membranes. Nat Struct Mol Biol 3, 125–127 (1996). https://doi.org/10.1038/nsb0296-125

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