The ligand-binding domain of nuclear receptors appears to contain a common fold that generates a conserved ligand-binding pocket. Their transcriptional activity is induced by ligand through realignment of a Gterminal helix to form a novel interacting surface.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Bourguet, W., Ruff, M., Chambon, P., Gronemeyer, H. & Moras, D. Nature 375, 377–382 (1995).
Renaud, J.-P. et al. Nature 378, 681–689 (1995).
Wagner, R.L. et al. Nature 378, 690–697 (1995).
Wurtz, J.-M. et al. Nature Struct. Biol. 3, 87–94 (1996).
Parker, M.G. Curr. Opin. Cell Biol. 5, 499–504 (1993).
Mangelsdorf, D.J. et al. Cell 83, 835–839 (1995).
Wurtz, J.-M. et al. Nature Struct. Biol. 3, 207 (1996).
Danielian, P.S., White, R., Lees, J.A. & Parker, M.G. EMBO J 11, 1025–1033 (1992).
Saatcioglu, F., Bartunek, P., Deng, T., Zenke, M. & Karin, M. Mol. Cell. Biol. 13, 3675–3685 (1993).
Barettino, D., Ruiz, M.D.M.V. & Stunnenberg, H.G. EMBOJ. 13, 3039–3049 (1994).
Durand, B. et al. EMBO J. 13, 5370–5382 (1994).
O'Donnell, A.L. & Koenig, R.J. Mol Endocrinol. 4, 715–20 (1990).
Cavailles, V. et al. EMBO J. 14, 3741–3751 (1995).
Halachmi, S. et al. Science 264, 1455–1458 (1994).
Ledouarin, B. et al. EMBO J. 14, 2020–2033 (1995).
Lee, J.W., Ryan, F., Swaffield, J.C., Johnston, S.A. & Moore, D.D. Nature 374, 91–94 (1995).
Vom Baur, E. et al. EMBO J in the press.
Onate, S.A., Tsai, S.Y., Tsai, M.-J. & O'Malley, B.W. Science 270, 1354–1357 (1995).
Kurokawa, R. et al. Nature 377, 451–454 (1995).
Horlein, A.J. et al. Nature 377, 397–104 (1995).
Chen, J.D. & Evans, R.M. Nature 377, 454–457 (1995).
Fawell, S.E., Lees, J.A., White, R. & Parker, M.G. Cell 60, 953–962 (1990).
Forman, B.M. et al. Mol Endocrinol. 3, 1610–1626 (1989).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Parker, M., White, R. Nuclear receptors spring into action. Nat Struct Mol Biol 3, 113–115 (1996). https://doi.org/10.1038/nsb0296-113
Issue Date:
DOI: https://doi.org/10.1038/nsb0296-113
This article is cited by
-
Glucocorticoid receptor control of transcription: precision and plasticity via allostery
Nature Reviews Molecular Cell Biology (2017)
-
Function of estrogen receptors in breast cancer
Breast Cancer (1997)