The cocrystal structure of TaqI DNA methyltransferase in complex with its specific DNA substrate adds to the growing list of structurally confirmed DNA base-flipping enzymes, and provides a basis for the general mechanism of AdoMet-dependent DNA N-methylation.
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Acknowledgements
We thank E. Weinhold for providing coordinates of the M•TaqI–DNA complex.
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Blumenthal, R., Cheng, X. A Taq attack displaces bases. Nat Struct Mol Biol 8, 101–103 (2001). https://doi.org/10.1038/84072
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DOI: https://doi.org/10.1038/84072
