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The surprisingly flexible PTB domain

Nature Structural Biology volume 6, pages 7–10 (1999)Cite this article

Abstract

The solution structure of the dNumb phosphotyrosine binding (PTB) domain bound to a novel peptide ligand demonstrates how PTB domains recognize structurally variable targets.

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Figure 1: Schematic diagram of signal transduction by modular proteins illustrated by the insulin signaling pathway.
Figure 2: Ribbon diagram of the dNumb PTB domain.
Figure 3: Surface representation of the dNumb PTB domain and Src SH2 domain.

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Authors and Affiliations

  1. the Leiden Institute of Chemistry, Leiden University , Einsteinweg 55, Leiden, 2300-RA, The Netherlands

    Gregg Siegal

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  1. Gregg Siegal
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Siegal, G. The surprisingly flexible PTB domain. Nat Struct Mol Biol 6, 7–10 (1999). https://doi.org/10.1038/4873

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