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Projection structure of a gap junction membrane channel at 7 Å resolution

Nature Structural Biology volume 4, pages 39–43 (1997)Cite this article

Electron cryo-microscopy and image analysis of frozen-hydrated, two-dimensional crystals of gap junction membrane channels formed by recombinant α1 connexin (Cx43) reveal a ring of transmembrane α-helices that lines the aqueous pore and a second ring of α-helices in close contact with the membrane lipids.

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Authors and Affiliations

  1. The Scripps Research Institute, Department of Cell Biology, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Rd, La Jolla, California, 92037, USA

    Vinzenz M. Unger, Nalin M. Kumar, Norton B. Gilula & Mark Yeager

  2. Division of Cardiovascular Diseases, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Rd, La Jolla, California, 92037, USA

    Mark Yeager

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  1. Vinzenz M. Unger
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  2. Nalin M. Kumar
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  3. Norton B. Gilula
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Unger, V., Kumar, N., Gilula, N. et al. Projection structure of a gap junction membrane channel at 7 Å resolution. Nat Struct Mol Biol 4, 39–43 (1997). https://doi.org/10.1038/nsb0197-39

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