The hormone-related protein PTHrP travels from the cytosol to the nucleus by binding to the transport factor importin β. Remarkably, the site of recognition of PTHrP is the N-terminal half of importin β, which also has Ran-binding and nucleoporin-binding capabilities and is, therefore, sufficient by itself to function in PTHrP nuclear import.
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Acknowledgements
I thank P. Riedinger for helping with the figures, and R. Bayliss, E. Fernandez and F. Bono for critical reading.
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Conti, E. The hitchhiker's guide to the nucleus. Nat Struct Mol Biol 10, 8–9 (2003). https://doi.org/10.1038/nsb0103-8
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DOI: https://doi.org/10.1038/nsb0103-8
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Xenopus importin beta validates human importin beta as a cell cycle negative regulator
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