Dipeptidyl peptidase IV contributes to the regulation of many physiological processes, most notably blood sugar homeostasis, by biting a dipeptide off the N terminus of specific peptides. A structure of this peptidase in complex with an inhibitor will assist efforts to regulate this regulator.
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References
Mentlein, R., Gallwitz, B. & Schmidt, W.E. Eur. J. Biochem. 214, 829–835 (1993).
McCaughan, G.W. et al. Immunol. Rev. 174, 172–191 (2000).
Hildebrandt, M., Klapp, B.F., Demuth, H.-U. & Hoffman, T. Dipeptidylpeptidases in Health and Disease (Kluwer/Plenum, New York; 2003).
Rasmussen, H.B., Branner, S., Wiberg, F.C. & Wagtmann, N. Nat. Struct. Biol. 10, 19–25 (2003).
Marguet, D. et al. Proc. Natl. Acad. Sci. USA 97, 6874–6879 (2000).
Ahren, B. et al. Diabetes Care 25, 869–875 (2002).
Fülop, V., Bocskei, Z. & Polgar, L. Cell 94, 161–170 (1998).
Ajami, K. et al. Biochemistry in the press (2002).
Brandt, W. Adv. Exp. Med. Biol. 477, 97–101 (2000).
Lambeir, A.M. et al. Biochim. Biophys. Acta 1340, 215–226 (1997).
Abbott, C.A. et al. Eur. J. Biochem. 267, 6140–6150 (2000).
Abbott, C.A., McCaughan, G.W., Levy, M.T., Church, W.B. & Gorrell, M.D. Eur. J. Biochem. 266, 798–810 (1999).
Richard, E., Alam, S.M., Arredondo-Vega, F.X., Patel, D.D. & Hershfield, M.S. J. Biol. Chem. 277, 19720–19726 (2002).
Nurizzo, D. et al. Nat. Struct. Biol. 9, 665–668 (2002).
Richardson, J.S. & Richardson, D.C. Proc. Natl. Acad. Sci. USA 99, 2754–2759 (2002).
Smith, T.F., Gaitatzes, C., Saxena, K. & Neer, E.J. Trends Biochem. Sci. 24, 181–185 (1999).
Xiong, J.P. et al. Science 294, 339–345 (2001).
Abbott, C.A. & Gorrell, M.D. in Ectopeptidases: CD13/Aminopeptidase N and CD26/Dipeptidyl-peptidase IV in Medicine and Biology, (eds. Langner, J. & Ansorge, S.) 171–195 (Kluwer/Plenum, New York; 2002).
Hühn, J., Olek, S., Fleischer, B. & von Bonin, A. Cell. Immunol. 192, 33–40 (1999).
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Gorrell, M. First bite. Nat Struct Mol Biol 10, 3–5 (2003). https://doi.org/10.1038/nsb0103-3
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DOI: https://doi.org/10.1038/nsb0103-3
