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The spliceosome shows its metal

Nature Structural Biology volume 8, pages 11–13 (2001)Cite this article

A conserved region of U6 small nuclear RNA has been implicated in binding an essential metal ion. Is this a glimpse of the spliceosome's catalytic core?

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Figure 1: The chemical pathway of pre-mRNA splicing.
Figure 2: Possible RNA components of the spliceosomal active site for the first step of pre-mRNA splicing.

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  1. the Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, 2153 North Campus Drive, Evanston, 60208-3500, Illinois, USA

    Erik J. Sontheimer

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  1. Erik J. Sontheimer
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Sontheimer, E. The spliceosome shows its metal. Nat Struct Mol Biol 8, 11–13 (2001). https://doi.org/10.1038/82979

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