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Neurodegenerative disease in 2015

Targeting tauopathies for therapeutic translation

Tau protein abnormalities are key pathogenic features of Alzheimer disease and other neurodegenerative diseases. In 2015, new studies of the less common tauopathies, including progressive supranuclear palsy, chronic traumatic encephalopathy and frontotemporal lobar degeneration, have identified in vivo biomarkers and mechanisms that initiate tau pathology.

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Figure 1: Advances in tau research in 2015.


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J.C.R. and A.L.B. are supported by NIH (grants U54NS092089 and R01AG038791) and the Tau Consortium.

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Correspondence to Adam L. Boxer.

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A.L.B. has received research support from Avid, Biogen, Bristol Myers Squibb, C2N Diagnostics, Cortice Biosciences, Eli Lilly, Forum Pharmaceuticals, Genentech and TauRx. He has served as a consultant for Asceneuron, Ipierian, Ionis (formerly Isis) Pharmaceuticals, Janssen and Merck. He serves on a Data and Safety Monitoring Board for Neurogenetics Pharmaceuticals. He has stock and/or options in Alector and Delos. J.C.R. declares no competing interests.

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Rojas, J., Boxer, A. Targeting tauopathies for therapeutic translation. Nat Rev Neurol 12, 74–76 (2016).

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