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Stroke

Are care and outcomes better for participants of stroke trials?

Nature Reviews Neurology volume 12, pages 498–499 (2016)Cite this article

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A recent observational study showed that patients with stroke who participated in clinical research received better care and had lower mortality than patients who did not participate. However, the study has several limitations, and the available evidence suggests that patients should not be advised that participation in research improves outcomes.

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References

  1. Cadilhac, D. Improved in-hospital outcomes and care for patients in stroke research. An observational study. Neurology 87, 206–213 (2016).

    Article  Google Scholar 

  2. Appelbaum, P. S. et al. False hopes and best data: consent to research and the therapeutic misconception. Hastings Cent. Rep. 17, 20–24 (1987).

    Article  CAS  Google Scholar 

  3. McCambridge, J., Witton, J. & Elbourne, D. R. Systematic review of the Hawthorne effect: new concepts are needed to study research participation effects. J. Clin. Epidemiol. 67, 267–277 (2014).

    Article  Google Scholar 

  4. Ginsberg, M. D. et al. High-dose albumin treatment for acute ischaemic stroke (ALIAS) part 2: a randomised, double-blind, phase 3, placebo-controlled trial. Lancet Neurol. 12, 1049–1058 (2013).

    Article  CAS  Google Scholar 

  5. Mohr, J. P. et al. Medical management with or without interventional therapy for unruptured brain arteriovenous malformations (ARUBA): a multicentre, non-blinded, randomised trial. Lancet 383, 614–621 (2014).

    Article  CAS  Google Scholar 

  6. Back, L., Nagaraja, V., Kapur, A. & Eslick, G. D. Role of decompressive hemicraniectomy in extensive middle cerebral artery strokes: a meta-analysis of randomised trials. Intern. Med. J. 45, 711–717 (2015).

    Article  CAS  Google Scholar 

  7. Vist, G. E., Bryant, D., Somerville, L., Birminghem, T. & Oxman, A. D. Outcomes of patients who participate in randomized controlled trials compared to similar patients receiving similar interventions who do not participate. Cochrane Database Syst. Rev. 3, MR000009 (2008).

    Google Scholar 

  8. Fernandes, N. et al. Outcomes for patients with the same disease treated inside and outside of randomized trials: a systematic review and meta-analysis. CMAJ 186, E596–E609 (2014).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. M.J.M and C.E.C. are at the School of Medicine, Medical Sciences and Nutrition, Polwarth Building, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZN, UK.,

    Mary Joan Macleod & Carl E. Counsell

Authors
  1. Mary Joan Macleod
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  2. Carl E. Counsell
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Corresponding author

Correspondence to Mary Joan Macleod.

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The authors declare no competing financial interests.

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Macleod, M., Counsell, C. Are care and outcomes better for participants of stroke trials?. Nat Rev Neurol 12, 498–499 (2016). https://doi.org/10.1038/nrneurol.2016.123

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