A new study provides detailed insight into changes in brain connectivity associated with prodromal Huntington disease. People with the disease-linked huntingtin allele who did not yet have substantial motor symptoms showed weakened frontostriatal connectivity and increased connection strength between frontal and posterior areas. These changes did not correlate with cognitive dysfunction, which was best predicted by increased whole-brain connectivity to the right thalamus and right inferior parietal lobe.
References
Harrington, D. L. et al. Network topology and functional connectivity disturbances precede the onset of Huntington's disease. Brain 10.1093/brain/awv145
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Reorganization of functional connectivity in patients with prodromal Huntington disease. Nat Rev Neurol 11, 370 (2015). https://doi.org/10.1038/nrneurol.2015.111
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DOI: https://doi.org/10.1038/nrneurol.2015.111