The GABAB receptor agonist R-baclofen (R-BAC) improves non-rapid eye movement sleep quality and alleviates cataplexy in a mouse model of narcolepsy, a new study has shown. Interestingly, R-BAC was found to be more effective than γ-hydroxybutyrate (GHB), a drug that has already been approved by the FDA for the treatment of narcolepsy. The results indicate that R-BAC warrants further investigation as a possible therapy for narcolepsy and other sleep disorders.
References
Black, S. W. et al. GABAB agonism promotes sleep and reduces cataplexy in murine narcolepsy. J. Neurosci. 10.1523/JNEUROSCI.0080-14.2014
Rights and permissions
About this article
Cite this article
R-baclofen shows promise as a treament for narcolepsy. Nat Rev Neurol 10, 308 (2014). https://doi.org/10.1038/nrneurol.2014.96
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrneurol.2014.96
