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Alzheimer disease

Lessons from immunotherapy for Alzheimer disease

Nature Reviews Neurology volume 10, pages 188–189 (2014)Cite this article

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Amyloid-β (Aβ) is suggested to have a pivotal role in the pathogenesis of Alzheimer disease (AD) and is a major therapeutic target. Recent phase III trials of the anti-Aβ monoclonal antibodies bapineuzumab and solanezumab, which failed to improve cognitive function in patients, provide valuable insights for the future development of immunotherapies.

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Acknowledgements

Y.-J.W. is supported by the National Natural Science Foundation of China (grant numbers 81270423 and 30973144) and the Natural Science Foundation Project of Chongqing Science and Technology Committee (grant number CSTC2010BA5004). Y.-J.W. thanks Professors Jun Tan and Brian Giunta at the University of South Florida, USA for critical reading of the paper.

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  1. Department of Neurology, Daping Hospital, Third Military Medical University, 10 Changjiang Branch Road, Yu-Zhong District, 400042, Chongqing, China

    Yan-Jiang Wang

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  1. Yan-Jiang Wang
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Correspondence to Yan-Jiang Wang.

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Wang, YJ. Lessons from immunotherapy for Alzheimer disease. Nat Rev Neurol 10, 188–189 (2014). https://doi.org/10.1038/nrneurol.2014.44

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