Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Alzheimer disease

The landscape of ageing—insights from AD imaging markers

Nature Reviews Neurology volume 10, pages 678–679 (2014)Cite this article

Subjects

The knowledge of imaging and fluid biomarkers gained from longitudinal observational studies of Alzheimer disease has recently been translated to a cross-sectional study of randomly selected, cognitively unimpaired elderly individuals. This is the first time that a two-feature biomarker classification system has been applied to a population-based cohort.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Sperling, R. A. et al. Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging–Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 7, 280–292 (2011).

    Article  Google Scholar 

  2. Jack, C. R. Jr et al. An operational approach to National Institute on Aging–Alzheimer's Association criteria for preclinical Alzheimer disease. Ann. Neurol. 71, 765–775 (2012).

    Article  Google Scholar 

  3. Wirth, M. et al. Associations between Alzheimer disease biomarkers, neurodegeneration, and cognition in cognitively normal older people. JAMA Neurol. 70, 1512–1519 (2013).

    PubMed  PubMed Central  Google Scholar 

  4. Vos, S. J. et al. Preclinical Alzheimer's disease and its outcome: a longitudinal cohort study. Lancet Neurol. 12, 957–965 (2013).

    Article  Google Scholar 

  5. Mormino, E. C. et al. Synergistic effect of β-amyloid and neurodegeneration on cognitive decline in clinically normal individuals. JAMA Neurol. http://dx.doi.org/10.1001/jamaneurol.2014.2031.

  6. Jack, C. R. Jr et al. Age-specific population frequencies of cerebral β-amyloidosis and neurodegeneration among people with normal cognitive function aged 50–89 years: a cross-sectional study. Lancet Neurol. 13, 997–1005 (2014).

    Article  Google Scholar 

  7. Parkinson Progression Marker Initiative. The Parkinson Progression Marker Initiative (PPMI). Prog. Neurobiol. 95, 629–635 (2011).

  8. Villemagne, V. L., Kim, S., Rowe, C. C. & Iwatsubo, T. Imago Mundi, Imago AD, Imago ADNI. Alzheimers Res. Ther. 6, 62 (2014).

    Article  Google Scholar 

  9. Mormino, E. C. et al. Amyloid and APOE ε4 interact to influence short-term decline in preclinical Alzheimer disease. Neurology 82, 1760–1767 (2014).

    Article  CAS  Google Scholar 

  10. Lim, Y. Y. et al. APOE and BDNF polymorphisms moderate amyloid β-related cognitive decline in preclinical Alzheimer's disease. Mol. Psychiatry http://dx.doi.org/10.1038/mp.2014.123.

Download references

Author information

Authors and Affiliations

  1. Department of Nuclear Medicine and Centre for PET, Austin Health, Melbourne, 145 Studley Road, Heidelberg, 3084, Vic, Australia

    Victor L. Villemagne

  2. The Florey Institute for Neuroscience and Mental Health, University of Melbourne, Genetics Lane, Royal Parade, Melbourne, 3010, Vic, Australia

    Colin L. Masters

Authors
  1. Victor L. Villemagne
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Colin L. Masters
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Victor L. Villemagne.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Villemagne, V., Masters, C. The landscape of ageing—insights from AD imaging markers. Nat Rev Neurol 10, 678–679 (2014). https://doi.org/10.1038/nrneurol.2014.214

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrneurol.2014.214

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing