Fatigue is a common symptom of multiple sclerosis (MS), but researchers now suggest that fatigue is a diagnostic sign of this disease in some individuals. In a study of 5,305 patients with newly diagnosed MS and with 3 years of prediagnosis health-care coverage, 1,534 (28.9%) had a fatigue-related disorder in the 2 years preceding diagnosis of MS. The researchers suggest careful history-taking and physical examination in patients who present with fatigue could identify transient neurological conditions that may herald MS.
ORIGINAL RESEARCH PAPER
Berger, J. R. et al. Fatigue heralding multiple sclerosis. Mult. Scler. J. doi:10.1177/1352458513477924
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Fatigue—a warning sign for multiple sclerosis?. Nat Rev Neurol 9, 184 (2013). https://doi.org/10.1038/nrneurol.2013.53