A recent study has used whole-exome sequencing, an 'extreme trait' design and imaging genetics to identify coding variants associated with hippocampal volume loss in Alzheimer disease. The research highlights the utility of next-generation sequencing and association studies involving quantitative traits for discovery of disease-related variants in neurodegeneration.
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Apostolova, L. 'Generation Next' in Alzheimer disease genetic studies. Nat Rev Neurol 9, 422–423 (2013). https://doi.org/10.1038/nrneurol.2013.133
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DOI: https://doi.org/10.1038/nrneurol.2013.133
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