Patients with multiple sclerosis (MS) often present with other immune-mediated disorders, such as ulcerative colitis and type 1 diabetes. Researchers in Sweden analysed data from a large register of patients with MS and their parents to determine whether the risk of such comorbidity has a genetic component. They found that, in contrast to index cases, parents of patients with MS did not show an increased likelihood of having an immune-mediated disorder compared with control parents, arguing against a genetic influence.
ORIGINAL RESEARCH PAPER
Roshanisefat, H. et al. Shared genetic factors may not explain the raised risk of comorbid inflammatory diseases in multiple sclerosis. Mult. Scler. doi:10.1177/1352458512438240
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Risk of comorbid inflammatory diseases in MS might not be genetically determined. Nat Rev Neurol 8, 242 (2012). https://doi.org/10.1038/nrneurol.2012.72
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DOI: https://doi.org/10.1038/nrneurol.2012.72