Psychiatric disorders in epilepsy have been considered a consequence of the seizure disorder. In recent years, however, a bidirectional relationship has been suggested. Two new studies have examined recent epidemiological data that further supports this hypothesis, highlighting common pathogenic mechanisms that operate in both conditions.
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References
Tellez-Zenteno, J. F., Patten, S. B., Jette, N., Williams, J. & Wiebe, S. Psychiatric comorbidity in epilepsy: a population-based analysis. Epilepsia 48, 2336–2344 (2007).
Hesdorffer, D. C., Hauser, W. A., Annegers, J. F. & Cascino, G. Major depression is a risk factor for seizures in older patients. Ann. Neurol. 47, 246–249 (2000).
Adelow, C., Andersson, T., Ahlbom, A. & Tomson, T. Hospitalization for psychiatric disorders before and after onset of unprovoked seizures/epilepsy. Neurology 78, 396–401 (2012).
Wotton, C. J. & Goldacre, M. J. Coexistence of schizophrenia and epilepsy: record-linkage studies. Epilepsia 53, e71–e74 (2012).
Pan, A. et al. Bidirectional association between depression and type 2 diabetes mellitus in women. Arch. Intern. Med. 170, 1884–1891 (2010).
Trimble, M. R. The Psychoses of Epilepsy (Raven Press, New York, 1991).
Quiske, A., Helmstaedter, C., Lux, S. & Elger, C. E. Depression in patients with temporal lobe epilepsy is related to mesial temporal sclerosis. Epilepsy Res. 39, 121–125 (2000).
Mula, M. et al. Clinical correlates of schizotypy in patients with epilepsy. J. Neuropsychiatry Clin. Neurosci. 20, 441–446 (2008).
Tebartz Van Elst, L. et al. Amygdala pathology in psychosis of epilepsy: a magnetic resonance imaging study in patients with temporal lobe epilepsy. Brain 125, 140–149 (2002).
Kanner, A. M. Depression and epilepsy: a bidirectional relation? Epilepsia 52 (Suppl. 1), 21–27 (2011).
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M. Mula is a consultant for and has received honoraria from Janssen, Pfizer and UCB pharma.
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Mula, M. Bidirectional link between epilepsy and psychiatric disorders. Nat Rev Neurol 8, 252–253 (2012). https://doi.org/10.1038/nrneurol.2012.69
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DOI: https://doi.org/10.1038/nrneurol.2012.69
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