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Stroke

Haemorrhage risk after thrombolysis—the SEDAN score

Nature Reviews Neurology volume 8, pages 246–247 (2012)Cite this article

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Despite the proven favourable risk–benefit ratio, thrombolytic therapy for acute stroke is perceived to carry a grave risk. A simple risk-rating system, the SEDAN score, allows clinicians to quantify elevated risk. Whether effective thrombolytic therapy should be withheld from any particular patient requires further study, including randomized trials of patients with elevated risk scores.

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References

  1. Lyden, P. Thrombolytic therapy for acute stroke—not a moment to lose. N. Engl. J. Med. 359, 1393–1395 (2008).

    Article  CAS  Google Scholar 

  2. [No authors listed] Intracerebral hemorrhage after intravenous tPA therapy for ischemic stroke. The NINDS tPA Stroke Study Group. Stroke 28, 2109–2118 (1997).

  3. Cucchiara, B. et al. Validation assessment of risk scores to predict postthrombolysis intracerebral haemorrhage. Int. J. Stroke 6, 109–111 (2011).

    Article  Google Scholar 

  4. Strbian, D. et al. Predicting outcome of IV thrombolysis-treated ischemic stroke patients: the DRAGON score. Neurology 78, 427–432 (2012).

    Article  CAS  Google Scholar 

  5. Strbian, D. et al. Symptomatic intracranial hemorrhage after stroke thrombolysis: the SEDAN score. Ann. Neurol. http://dx.doi.org/10.1002/ana.23546.

  6. Asplund, K. Clinimetrics in stroke research. Stroke 18, 528–530 (1987).

    Article  CAS  Google Scholar 

  7. Lyden, P. et al. National Institutes of Health Stroke Scale certification is reliable across multiple venues. Stroke 40, 2507–2511 (2009).

    Article  Google Scholar 

  8. Wardlaw, J. M. & Mielke, O. Early signs of brain infarction at CT: observer reliability and outcome after thrombolytic treatment—systematic review. Radiology 235, 444–453 (2005).

    Article  Google Scholar 

  9. Fagan, S. C., Bowes, M. P., Lyden, P. D. & Zivin, J. A. Acute hypertension promotes hemorrhagic transformation in a rabbit embolic stroke model: effect of labetalol. Exp. Neurol. 150, 153–158 (1998).

    Article  CAS  Google Scholar 

  10. [No authors listed] Generalized efficacy of tPA for acute stroke. Subgroup analysis of the NINDS tPA Stroke Trial. Stroke 28, 2119–2125 (1997).

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  1. Department of Neurology, Cedars-Sinai Medical Center, 8730 Alden Drive, Thalians Building, E 240, Los Angeles, 90048, CA, USA

    Patrick D. Lyden

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  1. Patrick D. Lyden
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The author declares no competing financial interests.

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Lyden, P. Haemorrhage risk after thrombolysis—the SEDAN score. Nat Rev Neurol 8, 246–247 (2012). https://doi.org/10.1038/nrneurol.2012.66

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