Generation of reactive oxygen species (ROS) by NADPH oxidase (NOX) contributes to brain damage during cerebral ischaemia. Researchers have now shown that proton flux through the voltage-gated proton channel Hv1 expressed on microglia supports NOX activity in mice. In a stroke model, trangenic mice lacking Hv1 showed lower infarct volumes and improved neurological scores compared with wild-type mice, together with reduced markers of cell death in the peri-infarct zone and lower ROS production.
ORIGINAL RESEARCH PAPER
Wu, L.-J. et al. The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke. Nat. Neurosci. doi:10.1038/nn.3059
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A role for proton channel Hv1 in ischaemic brain damage. Nat Rev Neurol 8, 179 (2012). https://doi.org/10.1038/nrneurol.2012.50
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DOI: https://doi.org/10.1038/nrneurol.2012.50
