Studies indicate a link between migraine and the presence of ischaemic lesions in the brain. Palm-Meinders et al. assessed structural brain changes in 203 patients with migraine 9 years after initial MRI. No difference in lesion progression was observed in men with migraine compared with men without migraine. However, women with migraine showed significantly more progression of deep white matter hyperintensities than did control women over the 9-year period, suggesting that women are more susceptible to migraine-induced white matter changes than are men.