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Multiple sclerosis

Which MRI findings predict MS development in children?

MRI-based diagnostic criteria for multiple sclerosis (MS) have been devised for use in adult populations, but diagnosis of MS in children remains a challenge. To address this issue, a new study attempts to identify MRI characteristics that predict development of MS in children with acute demyelinating syndromes.

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References

  1. Langer-Gould, A. et al. Incidence of acquired CNS demyelinating syndromes in a multiethnic cohort of children. Neurology 77, 1143–1148 (2011).

    Article  CAS  Google Scholar 

  2. Gorman, M. P., Healy, B. C., Polgar-Turcsanyi, M. & Chitnis, T. Increased relapse rate in pediatric-onset compared with adult-onset multiple sclerosis. Arch. Neurol. 66, 54–59 (2009).

    Article  Google Scholar 

  3. Yeh, E. A. et al. Magnetic resonance imaging characteristics of children and adults with paediatric-onset multiple sclerosis. Brain 132, 3392–3400 (2009).

    Article  CAS  Google Scholar 

  4. Amato, M. P. et al. Cognitive and psychosocial features in childhood and juvenile MS: two-year follow-up. Neurology 75, 1134–1140 (2010).

    Article  CAS  Google Scholar 

  5. Verhey, L. H. et al. MRI parameters for prediction of multiple sclerosis diagnosis in children with acute CNS demyelination: a prospective national cohort study. Lancet Neurol. 10, 1065–1073 (2011).

    Article  Google Scholar 

  6. McDonald, W. I. et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann. Neurol. 50, 121–127 (2001).

    Article  CAS  Google Scholar 

  7. Callen, D. J. et al. Role of MRI in the differentiation of ADEM from MS in children. Neurology 72, 968–973 (2009).

    Article  CAS  Google Scholar 

  8. Callen, D. J. et al. MRI in the diagnosis of pediatric multiple sclerosis. Neurology 72, 961–967 (2009).

    Article  CAS  Google Scholar 

  9. Ketelslegers, I. A. et al. A comparison of MRI criteria for diagnosing pediatric ADEM and MS. Neurology 74, 1412–1415 (2010).

    Article  CAS  Google Scholar 

  10. Polman, C. H. et al. Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria. Ann. Neurol. 69, 292–302 (2011).

    Article  Google Scholar 

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Yeh, E. Which MRI findings predict MS development in children?. Nat Rev Neurol 8, 185–186 (2012). https://doi.org/10.1038/nrneurol.2012.25

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