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The MAPT locus—a genetic paradigm in disease susceptibility

Understanding how genetic variation can confer susceptibility to neurological disease is an urgent priority. A new gene-expression study has explored the relationship between DNA sequence variation at the microtubule-associated protein tau (MAPT) locus and MAPT expression in the brain, providing an exciting new paradigm for the field.

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Figure 1: The MAPT gene locus and the tau protein isoforms.


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Work in the Wade-Martins laboratory has been supported by Alzheimer's Research UK, Cure PSP, The Wellcome Trust and the Monument Trust Discovery Award from Parkinson's UK.

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Wade-Martins, R. The MAPT locus—a genetic paradigm in disease susceptibility. Nat Rev Neurol 8, 477–478 (2012).

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