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Alzheimer disease

Insulin resistance and AD—extending the translational path

Two recent studies have carefully characterized amyloid-related brain insulin resistance in animal models of, and patients with, Alzheimer disease (AD). The researchers show that exendin-4, a glucagon-like peptide 1 receptor agonist, ameliorates pathology and symptoms in a mouse model of AD, suggesting a novel therapeutic approach to this disease.

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S. Craft receives research support from Kurve Technology in the form of insulin delivery devices.

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Craft, S. Insulin resistance and AD—extending the translational path. Nat Rev Neurol 8, 360–362 (2012).

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