Intensive glucose management, if begun early, diminishes the long-term complications of diabetes. Whether the cognitive domain also benefits from such therapy is not clear, and has remained subject to investigation. Do the new results from the ACCORD-MIND study settle the issue?
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Investigating the role of neuropathic pain relief in decreasing gait variability in diabetes mellitus patients with neuropathic pain: a randomized, double-blind crossover trial
Journal of NeuroEngineering and Rehabilitation Open Access 20 August 2014
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Strachan, M. W. R D Lawrence Lecture 2010. The brain as a target organ in type 2 diabetes: exploring the links with cognitive impairment and dementia. Diabet. Med. 28, 141–147 (2011).
[No authors listed] The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. N. Engl. J. Med. 329, 977–986 (1993).
[No authors listed] Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet 352, 837–853 (1998).
Musen, G. et al. The Impact of diabetes and its treatment on cognitive function among adolescents who participated in the DCCT. Diabetes Care 31, 1933–1938 (2008).
The Action to Control Cardiovascular Risk in Diabetes Study Group. Effects of intensive glucose lowering in type 2 diabetes. N. Engl. J. Med. 358, 2545–2559 (2008).
Launer, L. J. et al. Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomised open-label substudy. Lancet Neurol. 10, 969–977 (2011).
Miller, M. E. et al. The effects of baseline characteristics, glycaemia treatment approach and glycated haemoglobin concentration on the risk of severe hypoglycaemia: post hoc epidemiological analysis of the ACCORD study. BMJ 340, b5444 (2010).
Whitmer, R. A., Karter, A. J., Yaffe, K., Quesenberry, C. P. Jr & Selby, J. V. Hypoglycemic episodes and risk of dementia in older patients with type 2 diabetes mellitus. JAMA 301, 1565–1572 (2009).
Herzog, R. I., Sherwin, R. S. & Rothman, D. L. Insulin-induced hypoglycemia and its effect on the brain: unraveling metabolism by in vivo nuclear magnetic resonance. Diabetes 60, 1856–1858 (2011).
Murray, A. M. et al. Biomarkers of renal function and cognitive impairment in patients with diabetes. Diabetes Care 34, 1827–1832 (2011).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Herzog, R., Sherwin, R. Can tight glycemic control in diabetes benefit cognition?. Nat Rev Neurol 8, 124–126 (2012). https://doi.org/10.1038/nrneurol.2012.10
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrneurol.2012.10
This article is cited by
-
Investigating the role of neuropathic pain relief in decreasing gait variability in diabetes mellitus patients with neuropathic pain: a randomized, double-blind crossover trial
Journal of NeuroEngineering and Rehabilitation (2014)
