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Multiple sclerosis

The evolving diagnostic criteria for multiple sclerosis

Recent revisions to the diagnostic criteria for multiple sclerosis have simplified MRI definitions for dissemination of CNS lesions in space and time, and may enable an earlier and easier diagnosis of the disease. The validity of this approach needs to be assessed in real-world clinical practice.

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References

  1. McDonald, W. I. et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann. Neurol. 50, 121–127 (2001).

    Article  CAS  Google Scholar 

  2. Polman, C. H. et al. Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald Criteria”. Ann. Neurol. 58, 840–846 (2005).

    Article  Google Scholar 

  3. Swanton, J. K. et al. MRI criteria for multiple sclerosis in patients presenting with clinically isolated syndromes: a multicentre retrospective study. Lancet Neurol. 6, 677–686 (2007).

    Article  Google Scholar 

  4. Polman, C. H. et al. Diagnostic criteria for multiple sclerosis: 2010 Revisions to the “McDonald Criteria”. Ann. Neurol. 69, 292–302 (2011).

    Article  Google Scholar 

  5. Montalban, X. et al. MRI criteria for MS in patients with clinically isolated syndromes. Neurology 74, 427–434 (2010).

    Article  CAS  Google Scholar 

  6. Wingerchuk, D. M. et al. Revised diagnostic criteria for neuromyelitis optica. Neurology 66, 1485–1489 (2006).

    Article  CAS  Google Scholar 

  7. Charil, A. et al. MRI and the diagnosis of multiple sclerosis: expanding the concept of “no better explanation”. Lancet Neurol. 10, 841–852 (2006).

    Article  Google Scholar 

  8. Lai, H. M. et al. A preliminary study into the sensitivity of disease activity detection by serial weekly magnetic resonance imaging in multiple sclerosis. J. Neurol. Neurosurg. Psychiatry 60, 339–341 (1996).

    Article  CAS  Google Scholar 

  9. He, J., Grossman, R. I., Ge, Y. & Mannon, L. J. Enhancing patterns in multiple sclerosis: evolution and persistence. Am. J. Neuroradiol. 22, 664–669 (2001).

    CAS  PubMed  Google Scholar 

  10. Rovira, A. et al. A single, early magnetic resonance imaging study in the diagnosis of multiple sclerosis. Arch. Neurol. 5, 287–292 (2009).

    Google Scholar 

Download references

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Competing interests

M. Trojano has received honoraria for consultancy or speaking from Biogen, Sanofi-Aventis, Merck Serono and Bayer-Schering, and research grants from Merck Serono and Biogen.

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Trojano, M. The evolving diagnostic criteria for multiple sclerosis. Nat Rev Neurol 7, 251–252 (2011). https://doi.org/10.1038/nrneurol.2011.55

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