Statin use in patients with cerebral hemorrhage may not be without risk. A recent article analyzing existing statin data in a mathematical model suggests that statins might need to be avoided after intracerebral hemorrhage, particularly in patients with a lobar hemorrhage.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Furie, K. L. et al. Guidelines for the prevention of stroke in patients with stroke or transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 42, 227–276 (2011).
Morgenstern, L. B. et al. Guidelines for the management of spontaneous intracerebral hemorrhage: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 41, 2108–2129 (2010).
Westover, M. B., Bianchi, M. T., Eckman, M. H. & Greenberg, S. M. Statin use following intracerebral hemorrhage: a decision analysis. Arch. Neurol. doi:10.1001/archneurol.2010.356.
Iso, H., Jacobs, D. R. Jr, Wentworth, D., Neaton, J. D. & Cohen, J. D. Serum cholesterol levels and six-year mortality from stroke in 350,977 men screened for the multiple risk factor intervention trial. N. Engl. J. Med. 320, 904–910 (1989).
Amarenco, P. & Labreuche, J. Lipid management in the prevention of stroke: review and updated meta-analysis of statins for stroke prevention. Lancet Neurol. 8, 453–463 (2009).
Goldstein, L. B. et al. Hemorrhagic stroke in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels study. Neurology 70, 2364–2370 (2008).
Hill, M. D., Silver, F. L., Austin, P. C. & Tu, J. V. Rate of stroke recurrence in patients with primary intracerebral hemorrhage. Stroke 31, 123–127 (2000).
O'Donnell, H. C. et al. Apolipoprotein E genotype and the risk of recurrent lobar intracerebral hemorrhage. N. Engl. J. Med. 342, 240–245 (2000).
Bailey, R. D., Hart, R. G., Benavente, O. & Pearce, L. A. Recurrent brain hemorrhage is more frequent than ischemic stroke after intracranial hemorrhage. Neurology 56, 773–777 (2001).
Agarwal, V., Phung, O. J., Tongbram, V., Bhardwaj, A. & Coleman, C. I. Statin use and the prevention of venous thromboembolism: a meta-analysis. Int. J. Clin. Pract. 64, 1375–1383 (2010).
Author information
Authors and Affiliations
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Koch, S. Preventing recurrence of ICH—should statins be avoided?. Nat Rev Neurol 7, 193–194 (2011). https://doi.org/10.1038/nrneurol.2011.36
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrneurol.2011.36
This article is cited by
-
Association Between Paraoxonase Gene Polymorphisms and Intracerebral Hemorrhage in a Korean Population
Journal of Molecular Neuroscience (2015)