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Pediatrics

Neuroprotective effects of erythropoietin in preterm infants

The dramatic increase in survival of extremely premature infants has been associated with a growing population of individuals with neurodevelopmental disabilities. To date, clinical trials of neuroprotective agents in preterm infants have been limited, but new data suggest that erythropoietin might have important neuroprotective effects in these vulnerable infants.

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References

  1. Mikkola, K. et al. Neurodevelopmental outcome at 5 years of age of a national cohort of extremely low birth weight infants who were born in 1996–1997. Pediatrics 116, 1391–1400 (2005).

    Article  Google Scholar 

  2. Gonzalez, F. F. et al. Erythropoietin enhances long-term neuroprotection and neurogenesis in neonatal stroke. Dev. Neurosci. 29, 321–330 (2007).

    Article  CAS  Google Scholar 

  3. Juul, S. E. et al. Recombinant erythropoietin is neuroprotective in a novel mouse oxidative injury model. Dev. Neurosci. 30, 231–242 (2008).

    Article  CAS  Google Scholar 

  4. Siren, A. L., Fasshauer, T., Bartels, C. & Ehrenreich, H. Therapeutic potential of erythropoietin and its structural or functional variants in the nervous system. Neurotherapeutics 6, 108–127 (2009).

    Article  CAS  Google Scholar 

  5. Neubauer, A. P., Voss, W., Wachtendorf, M. & Jungmann, T. Erythropoietin improves neurodevelopmental outcome of extremely preterm infants. Ann. Neurol. doi: 10.1002/ana.21977.

  6. Sola, A., Wen, T. C., Hamrick, S. E. & Ferriero, D. M. Potential for protection and repair following injury to the developing brain: a role for erythropoietin? Pediatr. Res. 57, R110–R117 (2005).

    Article  Google Scholar 

  7. Bierer, R., Peceny, M. C., Hartenberger, C. H. & Ohls, R. K. Erythropoietin concentrations and neurodevelopmental outcome in preterm infants. Pediatrics 118, e635–e640 (2006).

    Article  Google Scholar 

  8. Brown, M. S., Eichorst, D., Lala-Black, B. & Gonzalez, R. Higher cumulative doses of erythropoietin and developmental outcomes in preterm infants. Pediatrics 124, e681–e687 (2009).

    Article  Google Scholar 

  9. Newton, N. R., Leonard, C. H., Piecuch, R. E. & Phibbs, R. H. Neurodevelopmental outcome of prematurely born children treated with recombinant human erythropoietin in infancy. J. Perinatol. 19, 403–406 (1999).

    Article  CAS  Google Scholar 

  10. Ohls, R. K. et al. Neurodevelopmental outcome and growth at 18 to 22 months' corrected age in extremely low birth weight infants treated with early erythropoietin and iron. Pediatrics 114, 1287–1291 (2004).

    Article  Google Scholar 

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Limperopoulos, C. Neuroprotective effects of erythropoietin in preterm infants. Nat Rev Neurol 6, 301–302 (2010). https://doi.org/10.1038/nrneurol.2010.66

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