Approximately one-third of patients with stroke exhibit persistent disability after the initial cerebrovascular episode, with motor impairments accounting for most poststroke disability. Exercise and training have long been used to restore motor function after stroke. Better training strategies and therapies to enhance the effects of these rehabilitative protocols are currently being developed for poststroke disability. The advancement of our understanding of the neuroplastic changes associated with poststroke motor impairment and the innate mechanisms of repair is crucial to this endeavor. Pharmaceutical, biological and electrophysiological treatments that augment neuroplasticity are being explored to further extend the boundaries of poststroke rehabilitation. Potential motor rehabilitation therapies, such as stem cell therapy, exogenous tissue engineering and brain–computer interface technologies, could be integral in helping patients with stroke regain motor control. As the methods for providing motor rehabilitation change, the primary goals of poststroke rehabilitation will be driven by the activity and quality of life needs of individual patients. This Review aims to provide a focused overview of neuroplasticity associated with poststroke motor impairment, and the latest experimental interventions being developed to manipulate neuroplasticity to enhance motor rehabilitation.
Training-based techniques, involving both physical and occupational therapy, continue to be the gold standard for poststroke motor rehabilitation
A better understanding of basic mechanisms of motor function and the pathophysiology of poststroke paresis will guide advances in neural repair and rehabilitation
Pharmacological, biological and electrophysiological techniques are being developed to augment neuroplasticity-induced and training-induced functional gains in patients with stroke
Exogenous cellular and neuroprosthetic technologies could enhance neural repair or offer alternative methods of motor control in patients with stroke
Combining measures of body function, activity, participation and patient quality of life will contribute to comprehensive goal setting in stroke rehabilitation
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This work was supported by the Intramural Research Program of the National Institute of Neurological Disorders and Stroke, NIH. The original illustrations used for Figure 1 were by G. Qushair of SciLingua.
The authors declare no competing financial interests.
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Dimyan, M., Cohen, L. Neuroplasticity in the context of motor rehabilitation after stroke. Nat Rev Neurol 7, 76–85 (2011). https://doi.org/10.1038/nrneurol.2010.200
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