Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Multiple sclerosis

Lesion location may predict disability in multiple sclerosis

Lesion location might turn out to be an important factor in long-term disability prediction in patients with primary progressive multiple sclerosis (MS). Using a lesion probability mapping approach, researchers have identified brain regions where the presence of MS lesions predicts an early need for bilateral walking support.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Charil, A. et al. Statistical mapping analysis of lesion location and neurological disability in multiple sclerosis: application to 452 patient data sets. Neuroimage 19, 532–544 (2003).

    Article  Google Scholar 

  2. Minneboo, A. et al. Infratentorial lesions predict long-term disability in patients with initial findings suggestive of multiple sclerosis. Arch. Neurol. 61, 217–221 (2004).

    Article  Google Scholar 

  3. Tintoré, M. et al. Brainstem lesions in clinically isolated syndromes. Neurology (in press).

  4. Swanton, J. K. et al. Early MRI in optic neuritis: the risk for disability. Neurology 72, 542–550 (2009).

    Article  CAS  Google Scholar 

  5. Bodini, B. et al. T2 lesion location really matters: a 10 year follow-up study in primary progressive multiple sclerosis. J. Neurol. Neurosurg. Psychiatry doi:10.1136/jnnp.2009.201574.

    Article  Google Scholar 

  6. Montalban, X. The pros and cons of early treatment of relapsing forms of multiple sclerosis. J. Neurol. 251, IV30–IV34 (2004).

    Article  Google Scholar 

  7. Kidd, D. et al. MRI dynamics of brain and spinal cord in progressive multiple sclerosis. J. Neurol. Neurosurg. Psychiatry 60, 15–19 (1996).

    Article  CAS  Google Scholar 

  8. Sastre-Garriga, J. et al. Metabolite changes in normal-appearing gray and white matter are linked with disability in early primary progressive multiple sclerosis. Arch. Neurol. 62, 569–573 (2005).

    Article  CAS  Google Scholar 

  9. Stevenson, V. L. et al. Primary and transitional progressive MS: a clinical and MRI cross-sectional study. Neurology 52, 839–845 (1999).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Mar Tintoré.

Ethics declarations

Competing interests

J. Sastre-Garriga and M. Tintoré are members of the European Magnetic Imaging in Multiple Sclerosis (MAGNIMS) group. The MAGNIMS group is responsible for the study that resulted in the paper by Bodini and colleagues.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sastre-Garriga, J., Tintoré, M. Lesion location may predict disability in multiple sclerosis. Nat Rev Neurol 6, 648–649 (2010). https://doi.org/10.1038/nrneurol.2010.161

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrneurol.2010.161

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing