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Neuropsychiatric disorders

Shared genetics of bipolar disorder and schizophrenia

Bipolar disorder and schizophrenia share common clinical features, and antipsychotic medications can treat both conditions effectively. An assessment of 73,929 people with bipolar disorder and/or schizophrenia from a Swedish registry found evidence that the two disorders also share more than half of their genetic determinants.

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Figure 1: Clinical features, genetic determinants, and treatment response overlap between bipolar disorder and schizophrenia.

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Correspondence to James B. Potash.

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Potash, J., Bienvenu, O. Shared genetics of bipolar disorder and schizophrenia. Nat Rev Neurol 5, 299–300 (2009). https://doi.org/10.1038/nrneurol.2009.71

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