Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Neuro-oncology

Isocitrate dehydrogenase mutations in low-grade gliomas

Nature Reviews Neurology volume 5, pages 303–304 (2009)Cite this article

Most grade II and grade III gliomas, as well as the secondary glioblastomas that arise from these tumors, possess point mutations that affect the substrate binding site of isocitrate dehydrogenase. These mutations are essentially unique to gliomas, seem to represent an early step in gliomagenesis, and confer a favorable prognosis.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Yan, H. et al. IDH1 and IDH2 mutations in gliomas. N. Engl. J. Med. 360, 765–773 (2009).

    Article  CAS  Google Scholar 

  2. Ohgaki, H. & Kleihues, P. Genetic pathways to primary and secondary glioblastoma. Am. J. Pathol. 170, 1445–1453 (2007).

    Article  CAS  Google Scholar 

  3. Schiff, D., Brown, P. D. & Giannini, C. Outcome in adult low-grade glioma: the impact of prognostic factors and treatment. Neurology 69, 1366–1373 (2007).

    Article  Google Scholar 

  4. Thompson, C. B. Metabolic enzymes as oncogenes or tumor suppressors. N. Engl. J. Med. 360, 813–815 (2009).

    Article  CAS  Google Scholar 

  5. Parsons, D. W. et al. An integrated genomic analysis of human glioblastoma multiforme. Science 321, 1807–1812 (2008).

    Article  CAS  Google Scholar 

  6. Balss, J. et al. Analysis of the IDH1 codon 132 mutation in brain tumors. Acta Neuropathol. 116, 597–602 (2008).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. University of Virginia Neuro-Oncology Center, Charlottesville, VA, USA

    David Schiff & Benjamin W. Purow

Authors
  1. David Schiff
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Benjamin W. Purow
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to David Schiff.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Schiff, D., Purow, B. Isocitrate dehydrogenase mutations in low-grade gliomas. Nat Rev Neurol 5, 303–304 (2009). https://doi.org/10.1038/nrneurol.2009.57

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrneurol.2009.57

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing