Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Stroke

Thrombolysis in childhood arterial ischemic stroke

Thrombolytic therapy is often used to treat arterial ischemic stroke in children, despite lack of FDA approval in this age group. The International Pediatric Stroke Study investigators have assessed the extent and nature of recombinant tissue plasminogen activator use in children in their registry, and have compared their findings with previously published case reports.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Roach, E. S. et al. Management of stroke in infants and children: a scientific statement from a Special Writing Group of the American Heart Association Stroke Council and the Council on Cardiovascular Disease in the Young. Stroke 39, 2644–2691 (2008).

    Article  PubMed  Google Scholar 

  2. Janjua, N., Nasar, A., Lynch, J. K. & Qureshi, A. I. Thrombolysis for ischemic stroke in children: data from the nationwide inpatient sample. Stroke 38, 1850–1854 (2007).

    Article  PubMed  Google Scholar 

  3. Amlie-Lefond, C. et al. Use of alteplase in childhood arterial ischaemic stroke: a multicentre, observational, cohort study. Lancet Neurol. 8, 530–536 (2009).

    Article  PubMed  Google Scholar 

  4. Rafay, M. F. et al. Delay to diagnosis in acute pediatric arterial ischemic stroke. Stroke 40, 58–64 (2009).

    Article  PubMed  Google Scholar 

  5. Fullerton, H. J., Wu, Y. W., Zhao, S. & Johnston, S. C. Risk of stroke in children: ethnic and gender disparities. Neurology 61, 189–194 (2003).

    Article  PubMed  Google Scholar 

  6. Lloyd-Jones, D. et al. Heart disease and stroke statistics—2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 119, e21–e181 (2009).

    PubMed  Google Scholar 

  7. Shellhaas, R. A., Smith, S. E., O'Tool, E., Licht, D. J. & Ichord, R. N. Mimics of childhood stroke: characteristics of a prospective cohort. Pediatrics 118, 704–709 (2006).

    Article  PubMed  Google Scholar 

  8. Albisetti, M. The fibrinolytic system in children. Semin. Thromb. Hemost. 29, 339–348 (2003).

    Article  CAS  PubMed  Google Scholar 

  9. National Institute of Neurological Disorders and Stroke Report of the Stroke Progress Review Group—September 2006 [online], (2006).

  10. Amlie-Lefond, C. et al. Thrombolysis in acute childhood stroke: design and challenges of the thrombolysis in pediatric stroke clinical trial. Neuroepidemiology 32, 279–286 (2009).

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Ethics declarations

Competing interests

L. C. Jordan is a co-investigator in the International Pediatric Stroke Study.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Jordan, L. Thrombolysis in childhood arterial ischemic stroke. Nat Rev Neurol 5, 473–474 (2009). https://doi.org/10.1038/nrneurol.2009.130

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrneurol.2009.130

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing