Mechanistic studies have implicated the alternative complement pathway, specifically C5a receptor activation, in the pathogenesis of anti-neutrophil cytoplasmic antibody-associated vasculitis. Results from a phase 2 trial suggest that C5a receptor blockade could enable the reduced use or complete withdrawal of steroids from induction protocols.
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Acknowledgements
R.K. is supported by the DFG grant KE 576/8-1 and an ECRC grant. The Experimental and Clinical Research Center is a joint cooperation between the Max-Delbrück Center for Molecular Medicine and the Charité Medical Faculty, Berlin, Germany.
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Kettritz, R. A CLEAR argument for targeting complement in ANCA vasculitis. Nat Rev Nephrol 13, 448–450 (2017). https://doi.org/10.1038/nrneph.2017.69
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DOI: https://doi.org/10.1038/nrneph.2017.69
